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pentobarbital will lessen the extent or outcome of fosaprepitant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Monitor Closely (one)pentobarbital will minimize the level or effect of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lack of, or diminished response to tofacitin